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Simple and sensitive diagnosis of invasive aspergillosis using triphasic DE?ZnO?APDMS microparticle composite

Abstract
The increasing mortality and incidence of invasive aspergillosis pose a serious threat to the health of immunocompromised populations. Herein, we synthesized triphasic DE?ZnO?APDMS microparticles for conidia enrichment and fungal cell wall disintegration without detergents when incubated with Aspergillus fumigatus. Using the triphasic DE?ZnO?APDMS microparticles and PCR assays, we developed a simple and sensitive fungal diagnostic assay for A. fumigatus. Tests with the cultured A. fumigatus samples revealed the advantages of the proposed diagnosis assay, including the ease of fungal cell wall disintegration, conidia capture, and the isolation of fungal DNA during sample preparation, compared to the commercial kit assay. Furthermore, the clinical utility of the proposed fungal diagnostic assay in 30 clinical samples showed superior sensitivity (100%) to the conventional kit (50%). The developed DE?ZnO?APDMS-based fungal diagnostic assay is a potentially valuable tool for diagnosing and monitoring invasive aspergillosis.

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